Pimafucin - instructions for use, indications and contraindications, reviews. The use of Pimafucin for thrush: indications, effectiveness What day pimafucin suppositories help

Pimafucin (INN - natamycin) is a macrolide antibiotic used as an antifungal agent. Irreversibly binding to the main component of the fungal cell membrane - ergosterol (resembling human cholesterol in function and structure), pimafucin seems to squeeze the cell membrane in its deadly embrace, destroying and ultimately destroying it. The drug is active against many pathogenic molds and yeasts, incl. genera Candida, Penicillium, Aspergillus, Fusarium, Cephalosporium. As for dermatophytes, they show resistance to pimafucin and require a different pharmacological approach. Features of the interaction of pimafucin with other drugs have not been described in the medical literature, because. not found in clinical and post-marketing studies.

Pimafucin is available in 3 dosage forms: enteric tablets, vaginal suppositories and cream for external use. It is curious that pimafucin tablets, being, unlike suppositories and cream, a dosage form for internal use, do not have a systemic effect on the body, because. are not absorbed in the gastrointestinal tract, therefore, the range of negative side reactions in this drug, unlike other antibiotics, is not at all wide.

Pimafucin tablets are taken with or without food. With candidiasis, the dosage regimen of the drug is as follows: 1 tablet four times a day (for children - half as much). Duration of treatment - 1 week. With persistent candidal vaginitis, pimafucin tablets, along with suppositories, are used to disinfect the infectious focus in the intestine. The dosage regimen is the same, the duration of treatment is 10-20 days. The disappearance of symptoms should not be the basis for abrupt withdrawal of the drug: this can be done only after a few days at the direction of the doctor.

Suppositories should be inserted into the vagina before going to bed in a supine position to the maximum possible depth. The average duration of use of this dosage form is 3-6 days, which, as a rule, is enough to eliminate vulvitis, vaginitis and vulvovaginitis.

As for the cream, it should be applied to areas affected by the fungus (vagina, skin, nails, diaper rash in children, external auditory canal) up to 4 times a day. With mycosis of the external auditory canal, before applying the cream, the ear should be cleaned of sulfur and other possible contaminants. After lubricating the affected area in the ear, a turunda made of wool or cotton is left.

Pharmacology

Antifungal polyene antibiotic from the macrolide group with a wide spectrum of action. It has a fungicidal effect. Natamycin binds the sterols of the cell membrane of the fungal cell, violating its integrity and function, which leads to cell death.

Most pathogenic yeast fungi are sensitive to natamycin, especially Candida albicans.

Dermatophytes are less sensitive to natamycin.

Resistance to natamycin has not been observed in clinical practice.

Pharmacokinetics

When applied to the skin and mucous membranes, it practically does not undergo systemic absorption, therefore it does not have a systemic effect.

Release form

Vaginal suppositories are torpedo-shaped, from white with a yellowish tint to light yellow with a brownish tint.

Excipients: cetyl alcohol - 690 mg, solid fat - 700 mg, sorbitan trioleate - 460 mg, polysorbate 80 - 460 mg, sodium bicarbonate - 69 mg, adipic acid - 64 mg.

3 pcs. - strips of aluminum foil (1) - packs of cardboard.
3 pcs. - strips of aluminum foil (2) - packs of cardboard.

Dosage

Assign 1 vaginal suppository for 3-6 days. The suppository is inserted into the vagina in the supine position, as deep as possible, 1 time / day at night.

In case of persistent vaginitis caused by Candida albicans, Pimafucin ® is additionally prescribed in the form of tablets for oral administration (1 tab. 4 times / day for 10-20 days) to sanitize the focus of candidal infection in the intestine. For the treatment of candidal lesions of the partner's genitals, Pimafucin ® is used in the form of a cream.

The duration of the course of treatment is set individually. After the disappearance of the symptoms of the disease, it is recommended to continue treatment for a few more days.

Overdose

Interaction

The drug interaction of the drug Pimafucin ® is not described.

Side effects

Local reactions: slight irritation, burning sensation are possible.

Indications

• vaginitis, vulvitis, vulvovaginitis, caused mainly by fungi of the genus Candida.

Contraindications

Hypersensitivity to the components of the drug.

Application features

Use during pregnancy and lactation

It is possible to use Pimafucin during pregnancy and lactation.

There are no data on adverse effects on the fetus.

special instructions

Vaginal suppositories dissolve quickly under the influence of body temperature, forming a foamy mass, which contributes to a uniform distribution of the active substance.

In the case of a chronic or recurrent infection, local treatment can be supplemented by the appointment of Pimafucin in the form of tablets and cream for external use.

Cetyl alcohol, which is part of vaginal suppositories, can cause a slight burning sensation in case of hypersensitivity to this component.

During menstruation, suppository therapy is interrupted.

During the use of suppositories, there is no need to exclude sexual intercourse. However, it is recommended to conduct an examination of sexual partners and, if a candidal lesion is detected, to conduct a course of treatment with Pimafucin. Also during the period of treatment should use barrier contraceptives.

Influence on the ability to drive vehicles and control mechanisms

Pimafucin ® does not affect the ability to drive vehicles and control mechanisms.

From this article you will learn: how and when to use Pimafucin from thrush. What kind of drug is this, can it be used not only by women, but also by men. The mechanism of action of Pimafucin. Release form: tablets, suppositories, cream.

Article publication date: 10/29/2017

Article last updated: 11/28/2018

Pimafucin is a drug with antifungal activity from the group of antimicrobial agents - macrolides. This is the trade name of the active substance Natamycin. Pimafucin is produced by an Italian pharmaceutical company, which is the reason for the rather high price of the drug.

This remedy is highly effective against yeast fungi of the genus Candida, which cause various forms of candidiasis, including genital lesions or thrush. Therefore, the drug is very often prescribed for the treatment of candidiasis. It can also be prescribed for the treatment of a fungal infection of a different type (not candidal), but with a lower therapeutic effect.

The advantages of Pimafucin in the treatment of candidal inflammation over other drugs from the group of antifungal agents:

• there is no development of fungal resistance to the drug during therapy;
• causes complete death of the pathogen;
• shows a high result in terms of complete cure;
• low toxicity of the drug (general effect on body systems);
• the minimum number of side effects and the rarity of their development;
• can be used in pregnant and lactating women, small children under 12 years old;
• does not penetrate into the general circulation when applied topically;
• available in all dosage forms, except for solution (tablets, cream, suppositories);
• can be used in women and men;
• a small number of contraindications for use.

Relative high cost (from 230 to 800 rubles, depending on the form of release and dosage) is the only negative quality of the drug, which does not allow it to be used more widely.

Only a doctor should prescribe therapy for thrush and another type of candidal infection with Pimafucin. You can address the problem to a gynecologist, urologist, dermatovenereologist or otorhinolaryngologist if there is a lesion of the oral cavity.

Indications for use

Pimafucin is used to treat inflammatory processes caused by yeast or yeast-like fungi. Most often used in the treatment of candidiasis with lesions:

• organs of the genitourinary system in women and men (labia, vagina, urethra, glans penis and foreskin);
• skin, its folds and skin derivatives (hair follicles, nails and periungual bed);
• ENT organs (tongue, lips, gums, pharynx, larynx, tonsils, sinuses, ears);
• digestive tract (esophagus, stomach, small and large intestine).

Candles from thrush Pimafucin, as well as tablets and cream, are very effective in cases of:

Acute, newly diagnosed form of pathology of any of the above localizations.

Diseases that arose against the background of taking antibacterial, hormonal and chemotherapeutic drugs.

Before and after surgical interventions on the genitals, intestines, esophagus, stomach in order to prepare, prevent and treat candidal infections.

When therapy should be carried out during the period of bearing a child or during breastfeeding.

If there is a violation of the liver and kidneys against the background of their chronic disease with a decrease in organ function (high levels of bilirubin and creatinine in blood samples).

The need to treat children under the age of 12, including newborns and premature babies.

Pimafucin is the main drug in the treatment of fungal inflammation of the intestine, as the only drug to which there is no resistance of the yeast flora (unlike Nystatin) and there are no common systemic manifestations (like Fluconazole and Itraconazole).

When Pimafucin should not be used

A feature of Pimafucin is the almost complete absence of contraindications for use. The drug can not be used if there is an individual allergic reaction, high sensitivity or intolerance:

• Natamycin - for all forms of medicine;
• starch, lactose, povidone, sucrose, bee products, talc, kaolin - for the tablet version of Pimafucin;
• polysorbate, adipic acid, sodium bicarbonate, cetyl alcohol - for vaginal suppositories.

Mechanism of drug action

The active substance Pimafucin blocks sterols - the main active elements of the fungal wall. This leads to a violation of their function of the exchange of nutrients with the external environment. The integrity of the cells of the pathogen is broken, and the microorganisms quickly die.

When Natamycin is applied to the skin and mucous membranes, the drug penetrates well into the inner layers, affecting all parts of the fungal colony, but is not absorbed into the blood vessels. Therefore, the drug does not affect the liver and kidneys.

When taking the tablet form of Pimafucin, its active substance is 85-90% excreted from the intestine with feces - absorption into the systemic circulation is minimal.

There are no data on the resistance of the fungal infection to the drug in clinical use. The drug always gives a good result in the treatment of candidiasis. It can be used for relapses of the disease an unlimited number of times, taking a break for 2-3 weeks.

The results of a laboratory study of the patient's biological material before (left) and after (right) the use of Pimafucin. Visible result of fungus suppression

Forms of drug release

Therapy regimens: doses and timing

When the symptoms of the pathology completely disappear during therapy, continue treatment for another 2-3 days.

In the treatment of a recurrent form of candidal lesions, a break in treatment should be at least one week.

Possible adverse effects

Negative effects during Pimafucin therapy are extremely rare - the drug is well tolerated by more than 95% of patients. All effects, with the exception of a severe allergic reaction (individual intolerance), do not require discontinuation of treatment and disappear on their own within a few days.

Application features

• In the case of treatment of a recurrent or chronic form of candidal infection, local therapy (suppositories, cream) must be supplemented with a tablet form of the drug in order to achieve a complete cure.
• If during the therapeutic course of Pimafucin menstruation begins, the treatment should be interrupted and the course should be started again after the end of the blood discharge.
• In the process of treating the genital form of candidiasis, you can continue to have sex, but use condoms.
• Be sure to examine your partner and, if a fungal infection is detected, treat it synchronously to avoid re-infection with candidiasis.
• Natamycin can be combined with other antifungal drugs - there will be no decrease in the effectiveness of therapy.
• Pimafucin is approved for use with reduced liver function.

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The site provides reference information for informational purposes only. Diagnosis and treatment of diseases should be carried out under the supervision of a specialist. All drugs have contraindications. Expert advice is required!

Dosage form

• tablets;
• vaginal capsules;
• cream.

Pharmacological properties

Unsatisfactory results of therapy were noted in patients who had been ill for a long time with recurrent candidal vaginitis and had repeatedly taken various antifungal medications. This, in turn, could contribute to the development of insensitivity of the infection to traditionally used drugs.

Thus, as a result of the treatment of candidal vaginitis with Pimafucin, complete recovery was recorded in the vast majority of pregnant women. This indicates the high efficacy of the drug in the treatment of candidal vaginitis. In addition, the absence of an embryotoxic effect of the drug, as well as a negative effect on the fetus, was noted.

Reviews

Anna, 36 years old, Moscow
Pimafucin has saved me more than once during pregnancy. The tool is completely harmless, has no side effects. Capsules are administered simply and without problems - no pain occurs. Perhaps this is one of the few drugs that can be safely used without a doctor's prescription, without risking either one's own health or the health of the child. True, there is one feature - during pregnancy, Pimafucin saves only for a certain period of time, because. microbiocenosis of the vagina is normalized only after

The drug "Pimafucin" is available in the form of vaginal suppositories, tablets and ointments. It is a broad spectrum antifungal agent. It is intended for the treatment of diseases of the organs of the female reproductive system, which provoke yeast-like fungi. In reviews of Pimafucin tablets for thrush, they are called the number one choice.

The drug demonstrates maximum effectiveness against candidiasis. Therefore, doctors begin therapy for thrush with the appointment of this remedy. The principle of action of the drug is to use pronounced fungicidal properties. Its active substance violates the integrity of pathogenic membranes and destroys microorganisms. The maximum resistance to Pimafucin suppositories, reviews and instructions confirm this, dermatophytes show.

Purpose

Most often, the drug is prescribed for the treatment of skin and mucous membranes affected by fungal infections of various types. Its use is also justified in the treatment of candidiasis. The agent is practically not absorbed from the gastrointestinal tract, from the surface of the skin and mucous membranes. Brief list of indications:

• fungal lesions of the nail plates;
• trichomoniasis;
• inflammation of the vulva;
• vaginitis;
• otomycosis;
• dermatological candidiasis.

oral form

The reviews and instructions for the use of Pimafucin tablets say that the remedy showed excellent results in the treatment and prevention of colonization of the intestines by fungi of the Candida family. Their uncontrolled reproduction provokes long-term use of antibiotics, hormonal preparations containing corticosteroids, cytostatics.

The cost of a package of 20 enteric-coated tablets in pharmacies is approximately 600 rubles.

Soft dosage form

The cream is prescribed to patients suffering from candidiasis of the skin and mucous tissues. And also in cases of damage by dermatophytes and other yeast-like fungi. In reviews of the Pimafucin cream, it is said that the average cost of the drug in Russian pharmacies is 360 rubles. The drug is supplied in metal tubes. Cream weight - 30 g.

suppositories

The main indication for taking suppositories is an infectious and fungal infection of the vulva. They are produced in two configurations. One is designed for short-term treatment of thrush and involves a set of three suppositories packed in a cardboard box. Its price is 300 rubles.

The reviews and instructions for the use of Pimafucin suppositories say that in the treatment of advanced vulvitis and vaginitis of fungal origin, it is advisable to purchase a second set. It consists of six suppositories. The cost of the set is 520 rubles.

Choice of dosage

In inflammatory processes caused by yeast-like fungi in the vulva and vagina, one suppository is prescribed for six days. In some cases, the use of the drug for nine days is allowed. To insert the candle into the vagina as deeply as possible, you need to take a horizontal position and relax.

In the reviews on the use of Pimafucin candles, they say that the standard prescription regimen is not always effective. In this case, the treatment can be supplemented with an oral form. Take four tablets a day. The oral form is responsible for the sanitation of the internal surface of the intestine, which can also serve as a focus for the colonization of yeast-like fungi.

The duration of the therapeutic course is ten days. To enhance the effect of therapeutic measures, a mild form of the remedy is prescribed. In the instructions and reviews of the Pimafucin ointment, they claim that it has proven effective in destroying fungal infections of the skin of the partner's genital organs. The cream is applied one or more times a day.

Balanoposthitis

As part of the drug therapy of the disease, the use of ointment has become widespread. It lubricates areas of the skin that have been colonized by fungi. The procedure is performed once a day. It is possible to increase the dosage. Instructions and reviews about "Pimafucin" in the form of a cream prove the high effectiveness of the drug.

Intestinal tissue damage

Thrush of the excretory system is treated with an oral form of the drug. Adults are advised to take four tablets each day. The duration of treatment is seven days. For children, the dose is halved. They need to take two pills. In reviews of Pimafucin, women give high marks to the results of treatment. They report the absence of side effects and good health during the therapeutic course.

Mycoses of the skin

With a dermatological lesion, a mild form of the drug is used. The ointment is applied to the affected area of ​​the skin once a day. If necessary, the number of procedures can be increased. In the reviews of women about "Pimafucin" it is mentioned that this remedy has found application in pediatric practice. It is used to treat diaper rash in babies.

Otomycosis

Fungal lesions of the ear organs are subject to therapy with natamycin, the main active ingredient of the mild form of Pimafucin. With open access to the affected areas, they are regularly lubricated with ointment. In the instructions and reviews of Pimafucin, it is recommended to pre-clean the auricle. A tampon is used to introduce the drug into the middle section. Its surface is abundantly smeared with cream and gently inserted into the ear canal.

The duration of therapy is set individually. You can not stop treatment after the disappearance of the main symptoms. In reviews of the use of "Pimafucin" it is said that the best results are achieved in cases where patients used the ointment for several days after the complete disappearance of the pathological manifestations of the underlying disease.

Taking during pregnancy

The remedy is recommended by leading obstetricians and gynecologists for the treatment of thrush during the period of gestation and breastfeeding. The dosage of the drug is indicated by the attending physician. To date, this medication is included in the group of first choice in the treatment of lesions of the mucous membranes and skin with fungal infections in pregnant women and during lactation. Judging by the reviews, every second woman takes Pimafucin in the 1st trimester.

Side effects

Despite the good tolerability of the drug by patients, the following negative manifestations were recorded by doctors:

• burning in the vagina and on the skin;
• diarrhea;
• bouts of nausea.

All of the above side effects do not require special treatment and do not lead to discontinuation of the drug. They go away on their own a few days after the start of the therapeutic course.

Contraindications

The main obstacle to treatment may be individual intolerance to the active component. In this case, we are talking about natamycin. Another contraindication, which is indicated in the instructions for use of Pimafucin tablets and in reviews, is porphyria.

Special cases

Uniform distribution of natamycin contained in suppositories over the inner surface of the vagina is ensured by foaming excipients under the influence of natural body temperature. In some cases, this drug can be included in the complex therapy plan for dermatomycosis of various origins.

Burning and irritation of the vaginal mucosa, which appear during the use of suppositories, occur due to the addition of the drug to the composition of the drug. In the composition of the drug, its share is insignificant, but sensitive patients may feel tingling and dryness. This is stated in the reviews of the Pimafucin candles.

If the fungal infection recurs after a certain period of time after the use of suppositories, then the appointment of an oral form of natamycin is recommended. During menstruation, candles are not used, since their effectiveness is minimal. During the course of the therapeutic course, partners are advised to use barrier contraception and undergo a thorough examination by specialized specialists.

Women who use suppositories do not need to give up their sexual life. The safety of the active substance has been proven. Therefore, natamycin is prescribed for the treatment of newborns. In reviews of Pimafucin candles, young parents mention that pediatricians prescribed this drug to their children.

Storage rules

All forms of the medicinal product must be kept in dry rooms. The recommended air temperature in the warehouse varies between 15-25 °C. The shelf life of the oral and soft form of the medicinal product established by the manufacturer Temmler Italia S.r.L. is four years.

Suppositories should be used after twenty-four months. The instructions and reviews on the use of "Pimafucin" say that when the storage temperature is exceeded, the candles are destroyed. Suppositories foam. Their shape changes.

The composition of the tablets

List of components:

• 100 mg of natamycin;
• 80 mg of potato starch;
• 5 mg PVP;
• 2.5 mg magnesium stearate;
• 66 mg lactose;
• 3 mg gelatin;
• 7 mg gum arabic;
• 30 mg calcium carbonate;
• 14 mg taolin;
• 21 mg talc;
• 18 mg phthalate;
• 122 mg sucrose.

Excipients:

• methyl p-hydroxybenzoate;
• triacetin;
• beeswax.

Composition of vaginal suppositories

Main components:

• 700 mg fat;
• 100 mg natamycin
• 460 mg sorbitol;
• 690 mg cetyl alcohol.

Excipients:

• polysorbate;
• sodium bicarbonate;
• adipic acid.

Soft Form Composition

Main components:

• 20 mg natamycin;
• 100 mg decyloleate;
• 135 mg cetostearyl alcohol;
• 150 mg propylene glycol.

Excipients:

• wax;
• sodium lauryl sulfate.

Patient reviews

In the reviews and instructions for the use of "Pimafucin" it appears that the therapeutic course is generally not associated with the appearance of side effects. The treatment is effective. Patients highlight the following benefits of using this drug:

• proven safety;
• almost complete absence of contraindications;
• availability;
• sale without a doctor's prescription;
• an abundance of analogues;
• prompt disposal of thrush;
• the possibility of use during pregnancy and breastfeeding.

Analogues

Preparations that contain natamycin:

• "Primafungin";
• "Pimafukort".

"Primafungin"

"Primafungin" is produced by JSC "Avexima" (Russian Federation). Suppositories are packed in a cardboard box of three. The dosage of this drug is fully consistent with the instructions listed in the instructions for use "Pimafucin". Customer reviews confirm this.

One suppository contains 100 mg of natamycin. The drug has practically no systemic effect on the body. If during use a pronounced burning sensation appears, you should stop using this remedy and seek additional advice from your doctor.

"Primafungin" is sold in pharmacies without a prescription. Its price is about 200 rubles. List of indications:

• inflammation of the vulva;
• vaginitis regardless of etiology;
• damage to the skin and mucous membranes by fungi of the Candida family.
• The drug is approved for use during lactation and pregnancy.

"Pimafukort"

This drug is considered an analogue of Pimafucin. The reviews and instructions say that it also includes neomycin and hydrocortisone. These components provide a complex therapeutic effect. The drug is produced by the Italian pharmaceutical company Temmler Italia S.r.L.

According to the manufacturer's description, this remedy has a pronounced anti-inflammatory effect. It perfectly fights fungal infections of the skin and mucous membranes. Used externally. Packed in cardboard boxes. The metal tube contains 15 g of cream.

"Pimafukort" is not a complete analogue of "Pimafucin", the instructions for use, in the reviews about this, are different. It says that the level of absorption of hydrocortisone through the skin without wound lesions is three percent. If the integrity of the epidermis is violated, this value doubles. If there is an infection on the skin, then the degree of absorption reaches 15%.

When using "Pimafucort" in the treatment of children, it should be borne in mind that their susceptibility is higher than that of adults. The older the child, the lower the absorption rate. There are few side effects. In reviews of Pimafucin and Pimafucort, some patients with sensitive skin insist that they feel a pronounced burning sensation and dryness of the skin on which the ointment was applied. Localized redness was noted. Sometimes women complained of itching.

If you note one of the above actions associated with taking Pimafukort, then we are talking about the manifestation of allergic reactions. In this case, the therapeutic course is canceled, and the drug must be replaced. True, usually these symptoms subside on the third day of using the cream. Similar moments are described by patients in their reviews of Pimafucin.

With prolonged use of the cream in children, a syndrome of suppression of the action of the adrenal cortex is diagnosed. Such a reaction is rare and only in those patients who applied occlusive dressings and applied the agent to large areas of the skin.

Instructions for use

When using "Pimafukort" in the eyelid area, you need to remember about the possibility of increasing intraocular pressure, which can lead to the further development of cataracts. In the therapeutic treatment of open wound surfaces, the risk of toxic effects is allowed. The reviews about "Pimafucin", produced in a mild form, talk about the safety of the drug for children.

"Pimafukort" can also be used in pediatrics, but under the supervision of a doctor. The list of indications includes all kinds of dermatoses, complications after fungal and bacterial infections. Contraindications include juvenile acne, anogenital itching, allergic reactions to the introduction of allergic vaccination vaccines. Do not use the cream for ichthyosis, the presence of open wound surfaces, viral diseases of the epidermis.

"Pimafukort" is prescribed with caution to children under one year old. And in the instructions, reviews of "Pimafucin" confirm this, there is no such restriction. The interaction of "Pimafucort" with other drugs is not described. Cross-type hypersensitivity has been reported when using neomycin with paromomycin, kanamycin, aminoglycosides, gentamicin.

Dosage

Adults and adolescents apply the cream twice a day. The course of treatment should not exceed fourteen days. Pimafukort ointment is the number one choice for the treatment of dermatoses. Occlusive dressings are contraindicated in small children. There were no cases of drug overdose.

Doctors admit the possibility of toxic effects when applying the cream to the surface of the middle ear, provided that the integrity of the eardrum is damaged. In this case, "Pimafucin" is recommended. User reviews confirm the absence of side effects. To enhance the effect of exposure, other forms of the drug are used.

"Natamycin"

This drug is considered one of the most effective antibiotics aimed at combating fungal infections. Most often, this remedy is prescribed for the treatment of thrush. In pharmacies, it is represented by suppositories, oral and soft forms. Like Pimafucin tablets, reviews say that Natamycin rarely causes side effects. It is almost non-toxic, therefore it is indicated for the treatment of pregnant women. The number of contraindications is minimal.

Instructions for use

The drug belongs to the group of tetraenes. Its main property is aimed at the destruction of a fungal infection. Nearly all known pathogenic organisms of similar origin fall under its spectrum of action. Like Pimafucin tablets, reviews of which are advisory in nature, Natamycin is prescribed by a doctor.

The main active ingredient is natamycin. It is obtained by production with an actinomycete. The drug breaks the membrane cells of the pathogenic flora of yeast and similar fungi, dermatomycetes and Trichomonas. Gram-positive cells show resistance to this medication.

"Natamycin" is produced by Russian, European and Asian pharmaceutical companies. The antibiotic is sensitive to sunlight, so it is packaged in a dark opaque container. The active substance natamycin is insoluble in water. It is produced in the form of a powder, which has a yellowish or white color. It dissolves in acetic acid, cooled to the lowest possible temperature, and in dimethylformamide.

If necessary, natamycin can be diluted with methyl alcohol. Like the Pimafucin tablets, the instructions and patient reviews confirm this, it does not have a systemic effect on the body. The substance is not absorbed from the gastrointestinal tract and from the surface of the skin. "Natamycin" is not prescribed to patients who suffer from tuberculosis. The use of the drug should be avoided by persons with individual intolerance to medicinal components.

Side effects of "Natamycin"

Doctors note the presence of adverse effects that may be associated with the use of the drug:

• diarrhea of ​​varying severity;
• vomit;
• nausea;
• burning;
• dryness.

There are no facts of overdose. Itravaginal suppositories are sold in pharmacies without a prescription. In other cases, pharmacists are asked to present the prescription of the attending physician. The cost of "Natamycin", produced in the form of a cream, is 260 rubles. Candles are sold at a price of 250 rubles. The oral form will cost 470 rubles. It is prescribed not only for women, but also for men.

Treatment of thrush

Modern medicine has a wide range of drugs intended for the treatment of fungal infections. In addition to analogues of "Pimafucin", pharmacological companies offer preparations based on fluconazole:

• "Flucostat";
• "Fluconazole-Teva";
• "Fluconazole-OBL";
• "Fluconazole-Stada";
• "Diflucan";
• "Mycosist";
• "Diflazon".

This active ingredient is also contained by "Vagisept" and "Safocid".

"Flucostat"

The capsules are produced by the Russian pharmaceutical company Pharmstandard. Minimum packing - 1 piece. Available in packs of two and seven capsules. The minimum cost is 200 rubles. For seven capsules they ask for 360 rubles. The main component of the drug is fluconazole. Its weight in the composition of the Flucostat capsules is 50 mg. Excipients:

• sodium lauryl sulfate;
• lactose;
• refined corn starch;
• magnesium stearate;
• aerosil;
• gelatin;
• food coloring;
• acetic acid;
• titanium dioxide.

Side effects of Flucostat

While taking the medicine, patients may experience the following pathological conditions:

• headache in different localization;
• convulsions;
• dizziness;
• nausea;
• leukopenia;
• trembling of the ventricles of the heart;
• thrombocytopenia;
• agranulocytosis;
• skin rash;
• anaphylactic shock;
• alopecia;
• erythema;
• necrolysis;
• violation of the urinary system.

Basic information about Flucostat

The drug is sold in pharmacies without a prescription. It is prescribed for the treatment of cryptococcosis and candidiasis. Also used to prevent bacterial infection in AIDS patients. The tool has a lot of contraindications:

• kidney failure;
• hepatic dysfunction;
• combined reception with homeopathic preparations;
• alcohol addiction;
• organic disease remedies;
• pathological changes in electrolyte balance.

"Fluconazole"

This drug is produced by many international and Russian pharmaceutical companies. Estimated price is 280 rubles. It contains 50 mg of fluconazole. The active substance is excreted in a volume of 80%. The drug is sold in the pharmacy network upon presentation of a prescription.

Indications:

• cryptococcal meningitis;
• mycosis of the epidermis;
• candidiasis of various origins.

Contraindications:

• children under 16;
• individual intolerance;
• lactation;
• taking cisapride;
• lactase deficiency;
• the use of terfenadine;
• congenital heart disorders.

"Diflucan"

This drug is produced by the world famous French company Pfizer. This is also an effective antifungal agent, which is aimed at treating thrush. The main component is fluconazole. Packages may contain 12, 7 or 4 capsules.

"Mikosist"

The medicine is sold in cardboard packs. They contain 4 capsules. The manufacturer is the Russian branch of the Gedeon Richter concern. Estimated cost - 730 rubles. The preparation contains 150 mg of the active substance. It is released according to the prescription of the attending physician.

Indications:

• cryptococcosis;
• candidiasis;
• fungal infections.
• Contraindications:
• lactation;
• the use of astemizole;
• lactose deficiency.

"Diflazon"

This prescription drug is manufactured by Vector-Pharm LLC, which is based in Slovenia. Produced in glass bottles with a capacity of 100 ml. The recommended storage temperature is 20°C. An effective antifungal drug is intended for infusion. As auxiliary substances, an aqueous solution of sodium chloride is used.

Side effects:

• headache;
• convulsions;
• neutropenia;
• violations of cardiac activity;
• swelling of the face;
• skin rash;
• necrolysis.

"Vagisept"

The drug contains fluconazole and metronidazole. The medicine is produced in Russia by Firn-M. The drug is dispensed by prescription. Estimated cost is 350 rubles. The cardboard box contains ten vaginal suppositories.

"Safocide"

A package of 12 tablets of the drug is sold at a price of 1681 rubles. Producer - JSC "Nizhpharm" (Russia). There are Indian counterparts. In addition to fluconazole, the drug contains the antibiotic azithromycin, secnidazole.

Since "Safocid" is a set of individual tablets, the set of ingredients for each is different.

Indications:

• various infections of the genitourinary system;
• trichomoniasis;
• urethritis;
• cervicitis;
• gonorrhea;
• vaginosis of bacterial origin;
• cystitis;
• inflammation of the tissues of the vulva;
• vaginitis.

At the first detection of symptoms of candidiasis, treatment should be started immediately. It copes well with the Pimafucin fungus from thrush, which can be found in any pharmacy, and in different forms. If you buy this drug in time and start treatment, then candidiasis will go away in a matter of days.

Almost every woman at least once in her life faced with such a disease as thrush. The main causative agent of this disease are fungi of the genus Candida, which instantly affect the mucous membrane of the genital organs. Not always the cause of candidiasis is direct contact with an infected person. Often, the weakening of the immune system is enough for fungi to damage the human body.

When should Pimafucin be used?

Instructions for use of the drug says that Pimafucin is necessary to eliminate fungal pathogens that have penetrated into all layers of the dermis and affected, first of all, the mucous membrane of the genital organs. Experts say that this medicine most effectively destroys fungal cells, minimally interfering with the normal work and life of a person as a whole.

A huge variety of forms of the drug allows you to get rid of the fungus in its various manifestations. In every pharmacy you can find Pimafucin tablets, ointment, suppositories and other forms. Any of these products is developed on the basis of the most powerful antibiotic natamycin, which does an excellent job with yeast fungi, molds and numerous dermatophytes.

• if fungal infections have developed on the mucous membranes and not only;
• in acute forms of candidiasis in both men and women;
• if yeast fungi appeared while taking strong antibacterial agents;
• with otomycosis;
• with nail and even intestinal candidiasis;
• for the treatment of vaginitis and vulvitis;
• to eliminate dermatomycosis.

If you correctly undergo a course of treatment for thrush with this remedy, then the disease will go away in a maximum of a week.

The most common forms of release of the drug

As already noted, the most powerful active ingredient of this medication is the antibiotic natamycin. All other auxiliary components differ significantly from each other depending on the form of release.

Most often, experts prescribe suppositories from Pimafucin thrush. They have a peculiar cylindrical shape, making them easy to insert into the vagina without discomfort. The color of these candles is usually white with a slight yellowish brown tint. The composition of the drug includes:

Often, professionals advise buying pills. The composition of this form includes: potato starch, talc, lactose, beeswax, titanium dioxide, kaolin, gelatin, sucrose, etc. As you can see, almost all components are natural, so there is a small chance that side effects will appear after taking the remedy.

In addition, there is a cream based on an antibiotic, organic alcohols, water and other equally important components. Suspension is extremely rare. Such a drug is recommended for rinsing in the event of oral candidiasis. Most often, this form of thrush appears in infants or, conversely, in the elderly. At the same time, the mucous membranes of the mouth become inflamed, acquire an unhealthy red tint. In some areas, a yellowish or white coating appears. Such a suspension in every possible way contributes to the removal of fungal trace elements.

How do Pimafucin suppositories help?

Pimafucin vaginal suppositories are designed for the complex treatment of candidiasis in women. Plus, the drug is able to help with other diseases that appeared later on after Candida fungal infections.

Most gynecologists recommend using suppositories strictly before bedtime. This is necessary so that the drug is completely dissolved overnight. You need to enter the candle while lying on your back. The average duration of treatment usually lasts no more than a week. Often itching and cheesy completely disappear on the third day of admission. But even if candidiasis has passed faster than the prescribed term of treatment, it is better not to stop and finish the course, otherwise the disease may return and even develop into a chronic form.

During menstruation, it is useless to use candles, since the drug is completely washed out with the blood. If signs of thrush are found on the external genital organs, it is necessary to use the ointment of the same manufacturer. At the same time, a permanent sexual partner, even in the absence of signs of candidiasis, is obliged to use an ointment, otherwise he risks getting sick. Only then can the sexual relationship continue.

With frequent relapses of thrush, you need to undergo complex treatment with tablets that create a special protective shell in the vagina. This is a proven method that really helps to restore normal microflora and immunity to a similar infection.

Recommendations for taking Pimafucin tablets for candidiasis

Intestinal candidiasis is difficult to identify. It usually manifests itself in the form of weakness, lack of appetite, as well as the presence of difficulties in the work process. Often, patients with this disease complain of frequent indigestion, loose stools, bloating and flatulence. In young children, intense colic appears at the same time.

The reproduction of Candida fungal organisms in the gastrointestinal tract contributes to the deterioration of the digestive system. The result of such violations is the occurrence of an allergic reaction to a certain product, vitamin deficiency, inflammation of the digestive tract, etc.

Experts say that it is from intestinal candidiasis that another type of thrush can develop, up to vaginal. Helps in this case, the drug Pimafucin in the form of tablets. If intestinal candidiasis is accompanied by vaginal, then it is recommended to use the remedy in parallel with suppositories.

The tablets of this manufacturer have a unique ability to deliver a medicinal substance to the site of infection. The drug is so strong that over time it is absorbed into the bloodstream and spreads throughout the body. Only thanks to complex treatment can you quickly get rid of the disease and protect yourself from re-infection in the near future.

How to use the cream for thrush?

Pimafucin cream for thrush is useful for both men and women. The paste-like mass should be applied to the external genitalia.

In the case of a disease in men, the same drug helps with balanoposthitis. It is especially important to treat areas of the skin of the penis if the pathology has begun to cause severe and inflammation of the glans penis. Treat the affected areas should be at least 2-3 times a day, otherwise the treatment will be practically useless.

It is also worth saying that candidiasis in men can also occur in a special form, when no symptoms appear and only severe pain during urination indicates that something is not right with the person. If you do not pay attention to this, then soon the thrush will cause more serious consequences, up to a venereal disease.

That is why Pimafucin ointment, when the first signs of thrush appear, is recommended for use by both men and young girls who have not yet had sexual intercourse. And, of course, we must not forget that Pimafucin can be treated not only with candidiasis. This cream is ideal for diseases of the outer ear caused by yeast-like fungi. After applying the ointment, carefully plug the ear canal with a swab.

Opinions of patients who took Pimafucin

Galina, 19 years old:

“A couple of months ago I first learned what thrush is. Having found the initial signs of this disease, she immediately turned to a doctor who advised the use of vaginal suppositories. At first I was afraid that this drug would somehow adversely affect my women's health. But after 4 days I realized that the treatment was not in vain, and I completely got rid of my problem. In the event of a recurrence of such a disease, I will use only Pimafucin.

Daria, 24 years old:

“The mother developed oral thrush. Since she does not like to visit doctors, she had to take everything into her own hands and consult with a specialist on her own. The doctor recommended rinsing the mouth with a special suspension of Pimafucin. Having bought the drug, she immediately offered it to her mother. In less than a week, the unpleasant symptoms disappeared.”

Gennady, 33 years old:

“It so happened that a couple of weeks ago there was sex with a previously unknown girl. A day after the event, I began to notice the presence of incomprehensible discharge from the penis. I had to visit a urologist. As it turned out, it was a thrush. The doctor recommended the use of Pimafucin ointment. Already on the 3rd day, candidiasis disappeared without a trace.

As you can see, the feedback from patients is only positive. If you notice that you are beginning to show the first signs of candidiasis, be sure to consult a specialist who will tell you how to take Pimafucin for thrush and how long the course of treatment should last in each case.