Testosterone Propionate: instructions for use of the solution. The use of testosterone propionate and its effect on the male body Interaction with other drugs

Latin name: Testosterone Propionate
ATX code: G03BA03
Active substance: Testosterone
Manufacturer: Farmak, Ukraine
Vacation from the pharmacy: On prescription
Storage conditions: 15 to 25 degrees
Best before date: 24 months

Testosterone Propionate is a therapeutic drug that allows men and women to restore the balance of androgen - the male hormone. The main component in the composition is testosterone. Produced as a solution for subcutaneous and intramuscular injections.

Indications for use

The drug is intended for both men and women.

Testosterone injections for the stronger sex are prescribed when there is a lag in sexual development, malfunctions in the functioning of the reproductive system, menopause, as well as vascular and nerve diseases. The drug is prescribed when prostate hypertrophy, acromegaly, eunuchoidism, impotence (developed due to endocrine disruptions), with a syndrome after surgical castration and a small amount of sperm are detected.

Testosterone injections for women are needed to treat disorders of the nerves and blood vessels that were caused by menopause, as well as to stop ovarian and breast cancer. Additionally, the main active component stops bleeding from the uterus in women of age, and also eliminates mastopathy, accompanied by tension in the mammary glands during PMS, uterine fibroids and proliferation of endometrial cells.

Composition and form of release

The main active ingredient is testosterone, the content of which in 1 ml of solution is 50 mg.

An additional ingredient is ethyl oleate.

The drug is produced in the form of a light yellow or slightly greenish oily liquid, which is packaged in 1 ml ampoules. The smell of the medicine is specific. Sold in a cardboard box of 10 pieces. Inside, in addition to the ampoules with the inscription Testosterone Propionate, instructions for use are enclosed in paper form.

Medicinal properties

Pharmacy testosterone has a special androgenic effect. It motivates the development and full-fledged work of the function of the external genital organs, the prostate gland, seminal vesicles, and also affects voice change, increased hair growth and more. It forms the structure of the body and some character traits, increases sexual desire and potency, enhances the development of male germ cells. The drug is able to reduce the amount of luteotropic and follicle-stimulating hormones produced.

In nature, testosterone is the opposite of estrogen.

Additionally, the agent is able to remove tumors of the mammary glands, have an anabolic effect, i.e. stimulate protein digestibility, reduce subcutaneous fat, retain potassium, phosphorus and sulfur (to properly synthesize protein), and deposit calcium to strengthen bones and strengthen muscles. If there is enough protein in the body, then the drug will start producing erythropoietin.

After the procedure, the solution slowly penetrates the body. Testosterone is sent to target organs, where it turns into 5-α-dihydrotestosterone, which interacts with cell membrane receptors, and then penetrates into its nucleus.

Communication with proteins reaches 98% of the drug.

Metabolism takes place in the liver. Urine removes the rest from the body. Only 6% is excreted from the intestine in unchanged form.

Dosage and administration

Price: 2000 rub

Guidelines for the use of the drug says that the introduction can be carried out both subcutaneously and intramuscularly. Dose per dose - 1 ampoule (1mg). The concentration can be 1% or 5%, the exact amount should be clarified by the attending physician.

The interval between injections should be 1 to 2 days.

The course of treatment is two weeks.

For women who have uterine bleeding due to a malfunction of the hypothalamus-pituitary-ovaries-adrenals system, the dosage is 1-2 ml of a 0.01 solution for 30 days.

Eunuchoidism, acromegaly, congenital retardation in sexual development imply 25-50 mg every other day. After the onset of recovery, they are transferred to maintenance - 5-10 mg every two days.

Male menopausal syndrome, impotence caused by malfunctions in the endocrine system, involves taking 10 mg of drugs every day or 25 mg 2 to 3 times a week. The course is 2-3 months.

With prostatic hypertrophy, 10 mg is prescribed every other day. Therapy lasts from 30 to 60 days.

The exact course and dosage of the drug for the treatment of male infertility is determined only by a specialist, based on the nature of the disease and the patient's individual indicators.

Use as a means to develop muscle and increase endurance is not recommended. However, some coaches advise taking Testosterone Propionate alone or in combination with other drugs.

The drug is forbidden to use during childbearing and breastfeeding, because testosterone can adversely affect the development of defects.

Contraindications and precautions

Injections Testosterone Propionate instructions for use are not allowed to be administered if there is:

• Oncology of the prostate or breast
• Intolerance to the elements of the composition
• Enlargement of the prostate
• Breast augmentation in men
• Problems in urination
• Malfunctions of the liver or kidneys
• Heart failure
• heart attack
• Excess calcium
• Diabetes
• edematous conditions
• Pregnancy and breastfeeding
• Astenization
• Old age in men.

The drug should not enter the vessels. To avoid side effects, the introduction is carried out slowly.

Arterial hypertension, epilepsy, kidney disease, migraine, heart failure, which are present during therapy, require constant monitoring by a specialist.

Reception by children will ensure the acceleration of development and growth.

Long reception also obliges to control body parameters.

If the patient has had injuries or surgeries in the recent past, then the appointment should be approached with caution, because. the drug can increase the tendency to thrombosis.

The tool can affect concentration, so it is better to refuse to drive vehicles or work with machinery.

Cross drug interaction

Rifampicin, barbiturate, Phenylbutazone, Carbamazepine and Phenytoin reduce the therapeutic effect.

If the patient suffers from hypogynadism, then specialists should prescribe additionally with estrogens and thyroid stimulants.

Vitamins, anabolics, phosphorus and calcium are enhanced by the drug.

The elimination of ciclosporin is slowed down by testosterone.

Androgens require a reduction in the dosage of hypoglycemic agents.

Testosterone can interfere with the metabolism of certain medications. Oral anticoagulants sometimes require dose reduction.

Oedema may occur due to cross interaction with corticosteroid or adrenocorticotropic hormones.

Alcohol and barbiturates reduce the activity of the described drug.

Side effects and overdose

During therapy, testosterone can cause the following negative reactions:

• Strong libido and frequent and prolonged erections
• Edema
• Hair growth where it should not be in women and a change in voice
• White skin of the face, its poor elasticity and slight swelling under the eyes
• Pain and atrophy of the mammary glands
• Pauses in breathing during sleep (apnea)
• Respiratory system disorders
• Enlargement of the genital organs in boys and adolescents
• Complete cessation of menstruation
• The risk of getting blood clots
• Arthralgia
• convulsions
• Rashes on the face (pimples, blackheads, inflammation)
• Jaundice
• Gastrointestinal disorders: nausea, diarrhea, abdominal pain
• allergies
• Weight gain
• Hyperhidrosis
• Vertigo
• Depression.

If for some reason the patient has taken higher doses for a long period of time, then the negative consequences described above will become a symptom of an overdose. Recommended treatment: discontinuation of testosterone therapy until the development of symptoms ceases.

In girls and women, a complete cessation of menstruation is possible due to a high dose of the drug.

Analogues

Catalent France Beineim, S.A., France

Price: 1200 rub

Andriol is a drug based on testosterone, which was created for the treatment of diseases of the genitourinary systems in men and women. Sold in capsules for oral administration.

Pros:

• Convenient release form
• Can be taken by athletes.

Minuses:

• Side effects
• Hard to find in pharmacies
• High price.

Testosterone propionate is an androgenic drug. Used as part of testosterone replacement therapy for:

Testicular failure (hypogonadism);

Pre-pubertal hypogenitalism with dysfunction of the gonads;

Erectile dysfunction of an endocrine nature;

male menopause;

Reducing the number of sperm in the ejaculate;

Osteoporosis associated with testosterone deficiency.

In women, the drug is used for induced menopause syndrome, hormone-dependent breast cancer, menopausal disorders, uterine fibroids. Testosterone propionate is a "fast" testosterone ester, which distinguishes it from testosterone enanthate, testosterone cypionate and other testosterone esters, which are slower to work, but have a longer effect. Promotes the development and increase of the functional activity of the external genitalia, prostate, testes, seminal vesicles. Responsible for the development of secondary sexual characteristics (coarsening of the voice, male-type hair growth). Determines the constitution of the body (the ratio of the proportion of adipose and muscle tissue). Participates in the formation of sexual behavior. Regulates sexual desire, increases erectile ability, stimulates the development of spermatozoa. Shows antagonistic action against estrogen. It exhibits an anabolic effect: it activates protein synthesis, prevents catabolism, promotes the accumulation and active involvement in biochemical processes of substances involved in protein synthesis - potassium, sulfur, phosphorus.

Increases bone mineral density. Promotes a set of skeletal muscles. The dosage regimen of testosterone propionate is determined on an individual basis depending on the clinical situation, the nature of the disease, the chosen treatment regimen, co-administered drugs, etc. Possible undesirable side effects: dyspepsia, intrahepatic cholestasis, edema, increased plasma calcium concentration. Local reactions may develop: hyperemia, itching and pain at the injection site. In addition, for all testosterone preparations, characteristic side effects are breast enlargement, prolonged and painful erections, increased libido (in men), virilization phenomena - a rough voice, male-type hair (in women). When using exogenous testosterone at a young age, growth retardation is possible due to the closure of the bone epiphyses. Testosterone propionate is contraindicated in malignant neoplasms of the prostate, breast enlargement in men, liver and kidney diseases, heart failure, during puberty in boys. If androgen-determined side effects occur, the drug course should be interrupted until they are eliminated, after which pharmacotherapy is resumed at lower dosages.

Pharmacology

Androgenic agent, contains testosterone esters. Affects the development and function of the external genitalia, prostate gland, seminal vesicles, as well as secondary sexual characteristics (voice, hairline). Participates in the formation of the constitution of the body and sexual behavior, activates libido and potency, stimulates spermatogenesis. It is an antagonist of female sex hormones - estrogen. It has an anabolic effect, which manifests itself in stimulating protein synthesis, delaying potassium, sulfur, phosphorus necessary for protein synthesis, enhancing calcium fixation in the bones and increasing muscle mass. Testosterone esters have different rates of absorption and excretion, which ensures the rapid development of the effect and long-term effect (up to 4 weeks) after a single injection.

Release form

1 ml - ampoules (10) - packs of cardboard.
1 ml - ampoules (5) - blister packs (2) - cardboard packs.

Dosage

Set individually, depending on the indications, stage of the disease, treatment regimen.

Interaction

When used together, inducers of microsomal liver enzymes (including rifampicin, barbiturates, carbamazepine, salicylates, phenylbutazone, phenytoin) reduce the effect of testosterone, a mixture of esters.

Side effects

From the digestive system: nausea, cholestatic jaundice, increased levels of aminotransferases.

Others: edema, hypercalcemia, dizziness, thrombophlebitis.

Local reactions: soreness at the injection site, redness and itching.

In women: the phenomena of masculinization (virilism) - coarsening of the voice, excessive hair growth on the face and body, pastosity of the face.

In men: priapism, increased sexual arousal, increased libido and frequent erections; gynecomastia.

In boys: precocious puberty, premature closure of the epiphyses of the bones.

Indications

Replacement therapy for primary and secondary hypogonadism, eunuchoidism; impotence of endocrine genesis, post-castration syndrome; male menopause; oligospermia; osteoporosis caused by androgen deficiency. Hormone-dependent tumors in women - breast cancer, as well as menopausal disorders in women (together with estrogens) and functional bleeding with hyperestrogenism; uterine fibroids.

Contraindications

prostate cancer, gynecomastia; dysfunction of the liver and kidneys; hypercalcemia, heart failure. Severe asthenization of patients, advanced age of men, puberty in boys.

Application features

Application for violations of liver function

Application for violations of kidney function

Use in children

special instructions

In the event of androgen-dependent side effects, treatment should be suspended until they disappear, and then continued with reduced doses of the drug.

In the course of treatment, the condition of patients with heart failure, arterial hypertension, epilepsy, migraine and impaired renal and hepatic function should be monitored.

Testosterone propionate: instructions for use and reviews

Latin name: Testosterone Propionate

ATX code: G03BA03

Active substance: testosterone (testosterone)

Producer: JSC "DALHIMFARM" (Russia)

Description and photo update: 26.10.2018

pharmachologic effect

Indications for use

Mode of application

Side effects

Contraindications

Release form

Storage conditions

Authors

Links

• The official instructions for the drug Testosterone propionate.
• Modern drugs: a complete practical guide. Moscow, 2000. S. A. Kryzhanovsky, M. B. Vititnova.

As well as an auxiliary ingredient ethyl oleate.

Release form

The solution is an oily liquid that has a light yellow or green tint. The solution has a specific smell. Testosterone is sold in ampoules of 1 ml, 10 ampoules fit into the package. The oil solution can be 1% or 5%.

pharmachologic effect

Wikipedia indicates that the drug provides a pronounced anabolic and androgenic activity, regulating the process of protein synthesis and the function of the male gonads.

Testosterone Propionate has a specific androgenic effect on the body. Its influence on the body provides stimulation of the development and function of the external genitalia, prostate, seminal vesicles, secondary male sexual characteristics. Testosterone takes part in the formation of male sexual behavior, and also participates in the construction of the constitution of the body, provides stimulation of spermatogenesis. Under the influence of testosterone, the production of luteotropic and follicle-stimulating hormones decreases.

Pharmacokinetics and pharmacodynamics

After subcutaneous or intramuscular injection, the substance is slowly absorbed from the place where it was introduced. Once in the bloodstream, testosterone gradually enters the organs, where it is reduced to 5-α-dihydrotestosterone, which interacts with cell membrane receptors. Then it penetrates into the nuclei of cells. In plasma, 98% of testosterone binds to proteins. Metabolism occurs in the liver, metabolites are excreted from the body through the kidneys. Another 6% unchanged is excreted through the intestines.

Indications for use

A testosterone injection is indicated for men who have sexual underdevelopment, disorders of the reproductive system of a functional nature, menopause (in the mature years of a man), as well as diseases of the vascular and nervous systems associated with it. Also, the drug is indicated for prostate hypertrophy, acromegaly, eunuchoidism, associated with endocrine disorders, with postcastration syndrome, oligospermia.

For women, the remedy is indicated for nervous and vascular disorders that are associated with a period, for the treatment of ovarian and breast cancer (women under 60 years of age). Testosterone is prescribed for uterine bleeding of a dysfunctional nature in women in old age; with, which is accompanied by tension of the mammary glands in the premenstrual period; at , .

Contraindications

Sportviki testifies that the remedy cannot be used for the following diseases and conditions:

• cancer of the prostate or mammary glands in men;
• individual high sensitivity to the active substance;
• gynecomastia;
• violations of the process of urination;
• disruption of the kidneys and liver;
• heart failure;
• hypercalcemia;
• swelling.

Testosterone is not administered to patients with severe asthenia, elderly men, women with and.

Side effects of testosterone propionate

During treatment with testosterone, in particular when taking large doses of it, the following side effects can be observed:

• increased sexual arousal, frequent erection;
• salt and water retention;
• masculinization in women (hair growth on the face and body, coarsening of the voice);
• pastosity of the face (deterioration of elasticity, slight swelling and whitening of the skin of the face);
• atrophy of the mammary glands, pain in the mammary glands.

If a woman takes large doses of the drug for treatment She may stop menstruating completely.

In boys and adolescents, during treatment with the drug, too active puberty may occur, the genitals may increase.

In addition, the following side effects may occur:

• , respiratory disorders;
• tendency to thrombosis;
• arthralgia, pain in the legs, cramps;
• nausea, ;
• , ;
• weight gain;
• With profuse sweating, nervousness,;
• local reactions in those places where the drug was injected.

Instructions for use (Method and dosage)

When taking Testosterone Propionate, the instructions for use must be carefully observed by the patient. The instruction provides that a solution of 1% or 5% is administered to the patient subcutaneously or intramuscularly in 1 ml. The interval between injections is 1-2 days, the course of treatment lasts from two weeks to several months.

How to take Testosterone Propionate for women is determined by the doctor depending on the disease and symptoms. At dysfunctional bleeding from the uterus 1-2 ml of a 1% solution is administered for about one month.

At eunuchoidism , acromegaly , congenital underdevelopment of the sex glands once every two days, 25-50 mg of the drug is administered. The duration of therapy depends on its effectiveness. Later, a maintenance dose is prescribed - 5-10 mg every other day.

At menopause in men , as well as at impotence of endocrine origin 10 mg of the drug is prescribed every day or 25 mg 2-3 times a week. Treatment should last 2-3 months.

At prostatic hypertrophy for 1-2 months, 10 mg is administered every other day.

How to inject Testosterone Propionate with male infertility , is determined by a specialist, taking into account the individual characteristics of the organism.

Doctors do not recommend taking the drug to healthy people for muscle development and increased endurance. However, with sports training and strong physical exertion, some trainers recommend a course of Testosterone Propionate solo or a combination of this drug with other means. For example, the course is assigned in parallel Winstrol . Winstrol is an anabolic steroid. A joint course of Testosterone with drugs is also possible. , and etc.

Overdose

If the drug is administered in large doses for a long time, the side effects described above may subsequently occur. In such a situation, treatment should be suspended, it can be continued only after the disappearance of symptoms associated with androgen dependence. In this case, smaller doses of testosterone should be administered.

Overdose in women may stop menstruation.

Interaction

The effect of Testosterone Propionate is reduced if combined with Rifampicin, barbiturates, Phenylbutazone, Carbamazepine, Phenytoin.

If the patient has severe hypogonadism, it is recommended to combine Testosterone Propionate with , with agents that stimulate thyroid function.

The drug enhances the effect of vitamins, anabolic drugs, drugs that contain phosphorus, calcium. Testosterone slows down elimination.

Under the influence of androgens, the hypoglycemic effect of insulin may increase, therefore, it may be necessary to reduce the dose of the hypoglycemic agent.

Possible influence on the metabolism of a number of drugs. There is also evidence that testosterone increases the level of activity of oral anticoagulants. Sometimes there is a need to reduce the dose of the latter.

With the simultaneous administration of Testosterone and corticosteroids or adrenocorticotropic hormone, the risk of edema increases.

Testosterone activity decreases with the simultaneous intake of alcohol and barbiturates.

Terms of sale

In the pharmacy, the medicine can be bought with a prescription.

Storage conditions

It is necessary to protect drugs from light, from access of children. Its storage temperature is from 15 to 25 degrees Celsius.

Best before date

You can store the solution for 2 years. In this case, you should consider how to store Testosterone Farmak correctly.

special instructions

When introducing the solution, it is important to ensure that it does not enter the vessels. To avoid negative local and general reactions, you need to administer the drug very slowly.

When treating with Testosterone, it is imperative to monitor the state of the body of people suffering from arterial hypertension, , kidney disease, , heart failure.

Before starting the administration of the drug, it is necessary to conduct an examination and exclude prostate cancer in men, as the likelihood of prostate hyperplasia increases.

In the treatment of children with Testosterone, their accelerated growth and too active maturation of bone tissue may be noted. Also, the growth zones of the epiphysis may close prematurely.

Those patients who take this medicine for a long period of time need to monitor some laboratory parameters: testosterone concentration, hematocrit, and also conduct liver function tests.

Due to the increased tendency to form blood clots when taking this drug, you should carefully take it after recent surgery or trauma.

When treating with the drug, it is desirable to refrain from driving and performing other actions that require accuracy.

Analogues

Analogues of Testosterone Propionate are other drugs that contain testosterone. These are the drugs Androgel , Sinandron , Testoviron and etc.

children

Due to the lack of data on the safety of such treatment, the drug is not recommended for use in the treatment of children.

During pregnancy and lactation

Since Testosterone Propionate can provoke the development of a teratogenic effect, the drug is contraindicated for the treatment of and. It is especially dangerous to take it in the first trimester of pregnancy.